Amantadine

Drug Levels and Effects:




Summary of Use during Lactation:


It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Amantadineis a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Correa N, Opler LA, Kay SR et al.Amantadinein the treatment of neuroendocrine side effects of neuroleptics. J Clin Psychopharmacol. 1987;7(2):91-5. PMID:2884239
2. Siever LJ. The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients. J Clin Psychopharmacol. 1981;1(1):2-7. PMID:6117579



Substance Identification:




Substance Name:

Amantadine

CAS Registry Number:

768-94-5

Drug Class:


  • Antiinfective Agents

  • Antiparkinson Agents

  • Antiviral Agents

  • Dopamine Agents


  • Administrative Information:




    LactMed Record Number:


    434


    Last Revision Date:


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