Amlodipine

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of amlodipine during breastfeeding, an alternate drug may be preferred.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


A woman took amlodipine for hypertension 5 mg daily beginning 2 weeks postpartum. Her exclusively breastfed infant was examined regularly and at 3 months of age was healthy and had normal physical and neurological development.[1]

One woman received amlodipine 2.5 mg orally twice daily during pregnancy for hypertension associated with glomerulonephritis. The dose was increased to 5 mg twice daily on day 2 postpartum. Her exclusively breastfed infant's growth was normal throughout the first year of life and no adverse effects were noted.[2]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Nifedipine,Nitrendipine


References:


1. Ahn HK, Nava-Ocampo AA, Han JY et al. Exposure to amlodipine in the first trimester of pregnancy and during breastfeeding. Hypertens Pregnancy. 2007;26:179-87. PMID:17469008
2. Szucs KA, Axline SE, Rosenman MB. Maternal membranous glomerulonephritis and successful exclusive breastfeeding. Breastfeed Med. 2010;5:123-6. PMID:20491564



Substance Identification:




Substance Name:

Amlodipine

CAS Registry Number:

88150-42-9

Drug Class:


  • Antihypertensive Agents

  • Calcium Channel Blockers

  • Vasodilator Agents


  • Administrative Information:




    LactMed Record Number:


    11


    Last Revision Date:


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