Drug Levels and Effects:

Summary of Use during Lactation:

Because no information is available on the use of amoxapine during breastfeeding, another drug may be preferred, especially while nursing a newborn or preterm infant. If amoxapine is required by the mother, it is not a reason to discontinue breastfeeding. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

Drug Levels:

Maternal Levels.

In one nonbreastfeeding woman who developed galactorrhea during use of amoxapine 250 mg daily, amoxapine was found to be qualitatively present at less than 20 mcg/L, but not quantifiable at 0.75 and 11.5 hours after the dose. Milk levels of 8-hydroxyamoxapine, an active metabolite of amoxapine , were 113 and 168 mcg/L at 0.75 and 11.5 hours after the dose, respectively.[1] No data are available on amoxapine in breastfeeding women.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Two cases of galactorrhea have been reported in nonbreastfeeding women who were taking amoxapine .[1][2] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider:



1. Gelenberg AJ.Amoxapine, a new antidepressant, appears in human milk. J Nerv Ment Dis. 1979;167:635-6. PMID:573779
2. Jaffe K, Zisook S. Galactorrhea in a patient treated with amoxapine . J Clin Psychiatry. 1978;39:821. PMID:569147

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Antidepressants

  • Serotonin Uptake Inhibitors

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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