Amphotericin B

Drug Levels and Effects:




Summary of Use during Lactation:


Although no information exists on the milk excretion ofamphotericinB, it is highly protein bound, has a large molecular weight and is virtually unabsorbed orally; therefore, most reviewers consider it acceptable to use in nursing mothers.[1][2]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


(Systemic) Fluconazole,(Topical) Clotrimazole,Miconazole,Nystatin


References:


1. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001;17:160-6. PMID:11847833
2. Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005;4:745-68. PMID:16011452



Substance Identification:




Substance Name:

AmphotericinB

CAS Registry Number:

1397-89-3

Drug Class:


  • Antifungal Agents


  • Administrative Information:




    LactMed Record Number:


    446


    Last Revision Date:


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