Antacids, Oral

Drug Levels and Effects:




Summary of Use during Lactation:


Although no published information on the aluminum,calciumormagnesiumcontent of milk during maternal antacid therapy could be found, additional intake of these minerals by a nursing mother is unlikely to surpass that found in other infant foods. In addition, oral absorption of aluminum andmagnesiumis poor. Because of these factors, reviewers generally consider antacid use during breastfeeding to be acceptable.[1][2][3][4] No special precautions are required.


Drug Levels:


Maternal Levels.

The aluminum content of human milk is normally lower than cow's milk and much lower than infant formula.[5][6]

Magnesiumis a normal component of human milk.[7] Whenmagnesiumis administered intravenously in large doses, milkmagnesiumlevels are increased only slightly.[8]

Calciumis a normal component of human milk.[7]

Alginicacidand simethicone, which are components of some antacids are not absorbed orally.[1][9]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Cimetidine,Famotidine,Nizatidine,Omeprazole,Pantoprazole,Ranitidine,Sucralfate


References:


1. Lewis JH, Weingold AB and the Committee of FDA-Related Matters, American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80 :912-23. PMID:2864852
2. Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options? Drug Saf. 1998;19:325-37. PMID:9804446
3. WHO Department of Child and Adolescent Health and Development. Breastfeeding and maternal medication. Recommendations for drugs in the eleventh WHO model list of essential drugs. 2002. http://whqlibdocwhoint/hq/2002/55732pdf
4. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther; 2005;22:749-57.
5. Fernandez-Lorenzo JR, Cocho JA et al. Aluminum contents of human milk, cow's milk, and infant formulas. J Pediatr Gastroenterol Nutr. 1999;28:270-5. PMID:10067727
6. Mandic ML, Grgic J et al. Aluminum levels in human milk. Sci Total Environ. 1995;170:165-70. PMID:7481740
7. Neville MC.Calciumsecretion into milk. J Mammary Gland Biol Neoplasia. 2005;10:119-28. PMID:16025219
8. Cruikshank DP , Varner MW, Pitkin RM. Breast milkmagnesiumandcalciumconcentrations followingmagnesiumsulfate treatment. Am J Obstet Gynecol. 1982;143:685-8. PMID:7091241
9. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998;14:259-62. PMID:10205441



Substance Identification:




Substance Name:

Antacids, Oral

Drug Class:


  • Antacids

  • Anti-Ulcer Agents

  • Gastrointestinal Agents


  • Administrative Information:




    LactMed Record Number:


    447


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.