Artemether and Lumefantrine

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use ofartemetherandlumefantrineduring breastfeeding. However, a dosage has been established for infants weighing as little as 5 kg,[1] so it is unlikely to adversely affect breastfed infants weighing 5 kg or more.

In general, very small amounts of antimalarial drugs are excreted in the breastmilk of lactating women. Because the quantity of antimalarial drugs transferred in breastmilk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must receive the recommended dosages of antimalarial drugs.[1] Tablets can be crushed and administered in breastmilk to enhance absorption in small infants.[2]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Arguin PM, Steele SF. Chapter 2. The pre-travel consultation. Malaria. In. Centers for Disease Control and Prevention. CDC Health Information for International Travel 2010. Atlanta: U.S. Department of Health and Human Services, Public Health Service. 2009. http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/malaria.aspx
2. Adjei GO, Goka BQ, Binka F, Kurtzhals JA.Artemether-lumefantrine: an oral antimalarial for uncomplicated malaria in children. Expert Rev Anti Infect Ther. 2009;7:669-81. PMID:19681693



Substance Identification:




Substance Name:

ArtemetherandLumefantrine

CAS Registry Number:

141204-94-6

Drug Class:


  • Anti-Infective Agents

  • Antimalarials


  • Administrative Information:




    LactMed Record Number:


    788


    Last Revision Date:


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