Drug Levels and Effects:

Summary of Use during Lactation:

Limited information indicates that baclofen has low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Monitor newborn infants for signs of sedation.

Drug Levels:

Maternal Levels.

A women with spastic paraplegia was given a single oral 20 mg dose of baclofen 14 days postpartum. A peak milk level of about 130 mcg/L occurred 4 hours after the dose. The half-life in milk was 5.6 hours.[1]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

An infant was born after exposure to baclofen in utero. The mother was taking baclofen 10 mg twice daily plus clonazepam 1 mg orally twice daily and sustained-release oxycodone 50 mg daily in divided doses. The infant was breast and bottle fed while the mother continued taking baclofen . Neonatal withdrawal symptoms necessitated phenobarbital administration. The infant also received baclofen 0.5 mg/kg daily in 4 divided doses that was weaned and decreased by day 9 of life. Neurologic examination was normal at discharge on day 16 and at 6-weeks of age.[2]

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.


1. Eriksson G, Swahn CG. Concentration of baclofen in serum and breast milk from a lactating woman. Scand J Clin Lab Invest. 1981;41:185-7. PMID:7313501
2. Moran LR, Almeida PG, Worden S et al. Intrauterine baclofen exposure: a multidisciplinary approach. Pediatrics. 2004;114:e267-9. PMID:15286268

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • GABA Agonists

  • Muscle Relaxants, Central

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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