Benazepril

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the low levels of benazepril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.


Drug Levels:


Benazapril is an inactive drug that is metabolized to the active metabolite benazaprilat. Benazaprilat is poorly absorbed orally.

Maternal Levels.

In 9 women (time postpartum not stated) given an oral dose of 20 mg of benazepril daily for 3 days, peak milk levels of 0.9 mcg/L of benazepril at 1 hour after the dose and 2 mcg/L of its active metabolite benazeprilat at 1.5 hours after the dose were detected. The authors estimated that the infant would receive a dose less than 0.14% of the mother's weight-adjusted dose of benazepril , mostly as benazeprilat.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Captopril,Enalapril,Quinapril


References:


1. Kaiser G, Ackerman R, Dieterle W et al.Benazepriland benazeprilat in human plasma and breast milk. Eur J Clin Pharmacol. 1989;36(suppl):A303. Abstract.



Substance Identification:




Substance Name:

Benazepril

CAS Registry Number:

86541-75-5

Drug Class:


  • Antihypertensive Agents

  • Angiotensin-Converting Enzyme Inhibitors


  • Administrative Information:




    LactMed Record Number:


    26


    Last Revision Date:


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