Benzalkonium Chloride

Drug Levels and Effects:




Summary of Use during Lactation:


Topical maternal application of benzalkoniumchlorideor benzethoniumchlorideor their presence as a preservative in pharmaceuticals would not be expected to cause any adverse effects in breastfed infants.


Drug Levels:


Maternal Levels.

A study randomized 80 consecutive term patients into 4 groups who received either benzethoniumchlorideor povidone-iodine as a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL. The calculated amount of iodine ingested by the infants in breastmilk during the first 5 days of life correlated well with the amount of povidone-iodine applied to their mothers' skin. Patients who received prepartum povidone-iodine had higher median breastmilk iodide levels on day 5 postpartum than those who received benzethoniumchloride(0.93 mg/L pre- and postpartum povidone iodine, 0.64 mg/L benzethoniumchloride). [1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


A study in Japan randomized 80 consecutive term patients into 4 groups who received either povidone-iodine or benzethoniumchlorideas a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL of solution. Infant thyrotropin levels were elevated in the infants whose mothers received topical povidone-iodine pre- and postpartum compared to infants whose mothers received benzethoniumchloride.[1]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Chlorhexidine,Povidone-Iodine


References:


1. Koga Y, Sano H, Kikukawa Y et al. Affect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol. 1995;21:581-5. PMID:8640469



Substance Identification:




Substance Name:

BenzalkoniumChloride

CAS Registry Number:

8001-54-5

Drug Class:


  • Antiinfective Agents, Local

  • Antibacterial Agents

  • Detergents

  • Preservatives, Pharmaceutical


  • Administrative Information:




    LactMed Record Number:


    511


    Last Revision Date:


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