Bepotastine

Drug Levels and Effects:




Summary of Use during Lactation:


There are no reports of infants breastfed during maternal therapy with bepotastine. Because absorption from the eye is limited, bepotastine would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excesssolutionwith an absorbent tissue.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


There are no reports of infants breastfed during maternal therapy with bepotastine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]


Possible Effects on Lactation:


Antihistamines in relatively high doses given byinjectioncan decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed. Low ophthalmic doses of bepotastine are unlikely to have the same effect on serum prolactin.


Alternate Drugs to Consider:


Desloratadine,Fexofenadine,Loratadine


References:


Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID:8498418
Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Investig. 1985;8:143-6. PMID:3928731
Pontiroli AE, De Castro e Silva E, Mazzoleni F, Alberetto M et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID:7228996



Substance Identification:




Substance Name:

Bepotastine

CAS Registry Number:

125602-71-3

Drug Class:


  • Anti-Allergic Agents

  • Antihistamines

  • Histamine H1 Antagonists


  • Administrative Information:




    LactMed Record Number:


    791


    Last Revision Date:


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