Bismuth Subsalicylate

Drug Levels and Effects:

Summary of Use during Lactation:

Because of the possibility of absorption of salicylate from the breastmilk by the infant, alternatives are preferred.[1]

Drug Levels:

Maternal Levels.

No published information was found on the use ofbismuthsubsalicylate during breastfeeding. Infant salicylate intake is estimated to be less than 1% of the maternal dose when both drug and metabolite are considered.[2]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

One case report of metabolic acidosis was caused by salicylate in a 16-day old breastfed infant whose mother was taking aspirin 650 mg every 4 hours for arthritis.[3] However, there was no measurement of salicylate in maternal serum or milk and it is unclear whether the infant had received any salicylate directly.

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider:

(Diarrhea) Loperamide,(Heartburn) Antacids,Cimetidine,Famotidine,Nizatidine,Omeprazole,Pantoprazole,Ranitidine


1. Lewis JH, Weingold AB and the Committee of FDA-Related Matters, American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912-23. PMID:2864852
2. Levy G. Salicylate pharmacokinetics in the human neonate. In, Morselli PL, Garattini S, Sereni F, eds. Basic and therapeutic aspects of perinatal pharmacology. 1975; Raven Press: New York:319-30.
3. Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. PMID:7449246

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Salicylates

  • Gastrointestinal Agents

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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