Bismuth Subsalicylate

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the possibility of absorption of salicylate from the breastmilk by the infant, alternatives are preferred.[1]


Drug Levels:


Maternal Levels.

No published information was found on the use ofbismuthsubsalicylate during breastfeeding. Infant salicylate intake is estimated to be less than 1% of the maternal dose when both drug and metabolite are considered.[2]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


One case report of metabolic acidosis was caused by salicylate in a 16-day old breastfed infant whose mother was taking aspirin 650 mg every 4 hours for arthritis.[3] However, there was no measurement of salicylate in maternal serum or milk and it is unclear whether the infant had received any salicylate directly.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


(Diarrhea) Loperamide,(Heartburn) Antacids,Cimetidine,Famotidine,Nizatidine,Omeprazole,Pantoprazole,Ranitidine


References:


1. Lewis JH, Weingold AB and the Committee of FDA-Related Matters, American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912-23. PMID:2864852
2. Levy G. Salicylate pharmacokinetics in the human neonate. In, Morselli PL, Garattini S, Sereni F, eds. Basic and therapeutic aspects of perinatal pharmacology. 1975; Raven Press: New York:319-30.
3. Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. PMID:7449246



Substance Identification:




Substance Name:

BismuthSubsalicylate

CAS Registry Number:

14882-18-9

Drug Class:


Bismuth
  • Salicylates

  • Gastrointestinal Agents


  • Administrative Information:




    LactMed Record Number:


    449


    Last Revision Date:


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