Botulin B

Drug Levels and Effects:




Summary of Use during Lactation:


No data exist on the medical use of botulinB(botulinum toxin) during breastfeeding. However, one infant was safely breastfed during maternal botulism and no botulinum toxin was detectable in the mother's milk or infant. Since the doses used medically are far lower than those that cause botulism, amounts ingested by the infant, if any, are expected to be insignificant and not cause any adverse effects in breastfed infants. No special precautions are required.


Drug Levels:


Maternal Levels.

Published information on the medical use of botulinBduring breastfeeding was not found as of the revision date.

A woman with documented botulism was given 2 vials of trivalent botulism antitoxin, 1 intravenously and 1 intramuscularly. A milk sample obtained 4 hours after administration of the antitoxin had no detectable botulinum toxin nor botulism organisms.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Published information on the medical use of botulinBduring breastfeeding was not found as of the revision date.

A woman developed botulism after ingesting fermented salmon eggs while breastfeeding her 8-month-old infant (extent not stated). Type A botulinum toxin was detected in the woman's blood and stools. No botulinum toxin was detected in the infant's blood or stool on the day the mother was admitted to the hospital and no botulism organisms were detected in the infant's stools. The infant developed no signs or symptoms of botulism even though she continued to nurse throughout the mother's hospitalization.[1]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Middaugh J. Botulism and breast milk. N Engl J Med. 1978;298:343. PMID:622098



Substance Identification:




Substance Name:

BotulinB

CAS Registry Number:

93384-44-2

Drug Class:


  • Bacterial Toxins

  • Neuromuscular Agents

  • Neurotoxins


  • Administrative Information:




    LactMed Record Number:


    522


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.