Bumetanide

Drug Levels and Effects:




Summary of Use during Lactation:


It is unknown if bumetanide is excreted into breastmilk. It should be avoided while breastfeeding a newborn because it may decrease milk flow or completely suppress lactation. Low doses in mothers whose lactation is well established are unlikely to suppress lactation. In general, alternate drugs are preferred.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information on bumetanide was not found as of the revision date. Intense diuresis, fluid restriction and breast binding have been used to suppress lactation immediately postpartum.[1][2][3] The added contribution of the diuretic to the other measures, which are effective in suppressing lactation, has not been studied. No data exist on the effects of loop diuretics on established, ongoing lactation.


Alternate Drugs to Consider:


Chlorothiazide,Hydrochlorothiazide


References:


1. Healy M. Suppressing lactation with oral diuretics. Lancet. 1961;1:1353-4.
2. Stout G. Suppression of lactation. Br Med J. 1962;1:1150. Letter.
3. Cominos DC, Van Der Walt A, Van Rooyen AJ. Suppression of postpartum lactation with furosemide. S Afr Med J. 1976;50:251-2. PMID:3858



Substance Identification:




Substance Name:

Bumetanide

CAS Registry Number:

28395-03-1

Drug Class:


  • Antihypertensive Agents

  • Loop Diuretics


  • Administrative Information:




    LactMed Record Number:


    36


    Last Revision Date:


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