Busulfan

Drug Levels and Effects:




Summary of Use during Lactation:


Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Busulfanin a dosage of 4 mg daily for 5 weeks was taken for myeloid leukemia by one woman while breastfeeding. Weekly monitoring found no adverse effects on her infant's leukocyte count or hemoglobin.[1]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Dependent on the condition being treated.


References:


1. Bounameaux Y, Durenne JM. [A case of leukemia in a lactating female: effect of treatment with busulfan on the infant]. Ann Soc Belge Med Trop. 1964;44:381-3. PMID:14259241



Substance Identification:




Substance Name:

Busulfan

CAS Registry Number:

55-98-1

Drug Class:


  • Antineoplastic Agents


  • Administrative Information:




    LactMed Record Number:


    37


    Last Revision Date:


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