Carbachol

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of carbacholophthalmicdrops during breastfeeding. Because of its short half-life, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[1] and have variable effects on serum prolactin.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Clarke G, Fall CH, Lincoln DW, Merrick LP. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin. Br J Pharmacol. 1978;63:519-27. PMID:566601
2. Muller EE, Locatelli V, Cella S et al. Prolactin-lowering and -releasing drugs: mechanisms of action and therapeutic applications. Drugs. 1983;25:399-432. PMID:6133737



Substance Identification:




Substance Name:

Carbachol

CAS Registry Number:

51-83-2

Drug Class:


  • Miotics

  • Muscarinic Agonists

  • Parasympathomimetics


  • Administrative Information:




    LactMed Record Number:


    754


    Last Revision Date:


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