Cefadroxil

Drug Levels and Effects:




Summary of Use during Lactation:


Cefadroxilis acceptable to use during breastfeeding. Limited information indicates that maternal doses of cefadroxil up to 1 gram produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.


Drug Levels:


Maternal Levels.

After a single 500 mg oral dose of cefadroxil in 5 women, peak milk levels ranged from 0.6 to 0.9 mg/L. Peak levels occurred from 5 to 6 hours after the dose with a average of 0.65 mg/L at 5 hours and 0.68 mg/L at 6 hours after the dose.[1]

After a single 1 gram oral dose of cefadroxil in 6 women who were 2 days postpartum, peak levels occurred 6 to 7 hours after the dose and averaged 1.83 mg/L (range 1.2 to 2.4 mg/L).[2]

After a single 500 mg oral dose of cefadroxil in 2 or 3 women, peak milk levels of 0.4 mg/L occurred 4 hours after the dose.[3]

In all of the above studies, cefadroxil was undetectable in most women's milk for the first hour after the dose.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Takase Z, Shirafuji H, Uchida M. Experimental and clinical studies of cefadroxil in the treatment of infections in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 2):424-31.
2. Kafetzis DA, Siafas CA, Georgakopoulos PA et al. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981;70:285-8. PMID:7246123
3. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60.



Substance Identification:




Substance Name:

Cefadroxil

CAS Registry Number:

50370-12-2

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Cephalosporins


  • Administrative Information:




    LactMed Record Number:


    42


    Last Revision Date:


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