Ceftazidime

Drug Levels and Effects:




Summary of Use during Lactation:


Ceftazidimeis acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftazidime up to 2 grams produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.


Drug Levels:


Maternal Levels.

Ceftazidime2 grams was given to 11 women intravenously every 8 hours for 5 days. The average trough milk level was 3.8 mg/L before the next dose, 5.2 mg/L 1 hour after the dose and 4.5 mg/L 3 hours after the dose. These differences were not statistically significant. The average drug concentrations in milk were 3.9 mg/L for samples before the seventh dose and 4.9 mg/L in milk samples after the seventh dose, but this difference was not statistically significant. There was no correlation between the mother's weight and the ceftazidime milk levels.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Blanco JD, Jorgensen JH, Castaneda YS et al.Ceftazidimelevels in human breast milk. Antimicrob Agents Chemother. 1983;23:479-80. PMID:6342531



Substance Identification:




Substance Name:

Ceftazidime

CAS Registry Number:

78439-06-2

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Cephalosporins


  • Administrative Information:




    LactMed Record Number:


    54


    Last Revision Date:


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