Ceftibuten

Drug Levels and Effects:




Summary of Use during Lactation:


Ceftibutenis acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftibuten up to 200 mg produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.


Drug Levels:


Maternal Levels.

After a single 200 mg oral dose of ceftibuten in 6 women, the drug was undetectable (<1 mg/L) at any time up to 24 hours after the dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Barr WH, Lin CC, Radwanski E et al. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991;14:93-100. PMID:2013216



Substance Identification:




Substance Name:

Ceftibuten

CAS Registry Number:

97519-39-6

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Cephalosporins


  • Administrative Information:




    LactMed Record Number:


    55


    Last Revision Date:


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