Chlorpropamide

Drug Levels and Effects:




Summary of Use during Lactation:


It appears that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]


Drug Levels:


Maternal Levels.

No studies on the excretion of chlorpropamide into breastmilk have been published. The manufacturer states that a level of 5 mg/L was found in breastmilk 5 hours after a 500 mg dose; however, no study details were given.[1][3]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acarbose,Glyburide,Insulin,Metformin,Tolbutamide


References:


1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID:9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID:15701580
3. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. 6th ed. Baltimore: Williams & Wilkins, 2002.



Substance Identification:




Substance Name:

Chlorpropamide

CAS Registry Number:

94-20-2

Drug Class:


  • Hypoglycemic Agents

  • Sulfonylurea Compounds


  • Administrative Information:




    LactMed Record Number:


    66


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.