Cisapride

Drug Levels and Effects:




Summary of Use during Lactation:


Cisapride was removed from the market in the United States by the US Food and Drug Administration because of cardiac toxicity. Because of the low levels of cisapride in breastmilk, its use is acceptable in nursing mothers if it is required.


Drug Levels:


Maternal Levels.

Ten women who averaged 1.2 days postpartum were given cisapride 20 mg orally every 8 hours for 4 days. Cisapride milk samples obtained before and 1 hour after the midday dose on day 4 were 4.8 mcg/L and 6.2 mcg/L, respectively.[1] The peak concentration corresponds to a maximum dose of 0.93 mcg/kg daily which is less that the 0.6 to 0.8 mg/kg daily infant dosage and about 0.1% of the maternal weight-adjusted dosage.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Metoclopramide


References:


1. Hofmeyr GJ, Sonnendecker EWW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986;30:735-6. PMID:3770067



Substance Identification:




Substance Name:

Cisapride

CAS Registry Number:

81098-60-4

Drug Class:


  • Gastrointestinal Agents

  • Serotonin Agonists


  • Administrative Information:




    LactMed Record Number:


    621


    Last Revision Date:


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