Cocaine

Drug Levels and Effects:




Summary of Use during Lactation:


Cocaine should not be used by nursing mothers or smoked (such as with "crack") by anyone in the vicinity of infants because the infants may be exposed by inhaling the smoke.[1][2] Newborn infants are extremely sensitive to cocaine because they have not yet developed the enzyme that inactivates it. Cocaine and its metabolites are detectable in breastmilk, although data are from random breastmilk screening rather than controlled studies because of ethical considerations in administering cocaine to nursing mothers. No data are available on the medical use of cocaine in nursing mothers. Cocaine breastmilk concentrations have varied over 100-fold in these reports. However, because of its chemical nature, high concentrations of cocaine are usually expected in milk.[3][4] Serious adverse reactions have been reported in a newborn infant exposed to cocaine via breastmilk. Selected mothers with a history of cocaine abuse who are not currently using cocaine can breastfeed their infants with monitoring of the mother and infant for cocaine exposure. Among these mothers, some have proposed that breastfeeding be discontinued only for those infants who test positive for cocaine exposure.[5]

Other factors to consider are the possibility of positive urine tests in breastfed infants which might have legal implications, and the possibility of other harmful contaminants in street drugs.


Drug Levels:


Cocaine is metabolized to benzoylecgonine which serves as a marker for cocaine ingestion. Other cocaine metabolites include ecgonine methyl ester and norcocaine. When cocaine and alcohol are taken together, cocaethylene is produced; its metabolite is ethylbenzoylecgonine. Both of these compounds are markers for concurrent use of cocaine and alcohol.

Maternal Levels.

A woman reported using 500 mg of cocaine intranasally over a 4-hour period. Her milk contained about 10 to 15 mcg/L of cocaine 12 hours after ingestion that slowly decreased until 36 hours after the last use when it was unmeasurable. The benzoylecgonine concentration in her breastmilk was about 400 mcg/L at 12 hours after ingestion and dropped to undetectable levels by 36 hours post-ingestion.[6]

Screening of breastmilk samples of postpartum women who admitted to having used cocaine prepartum found primarily cocaine and benzoylecgonine in breastmilk. Ecgonine methyl ester was usually not detected and only traces of norcocaine were detected, unless cocaine concentrations were very high. One such subject had a concentration of 12.1 mcg/L of cocaine, 4.1 mcg/L of benzoylecgonine and 119 mcg/L of norcocaine in her breastmilk.[7]

Ethylbenzoylecgonine has been found in the breastmilk of mothers who ingested cocaine and alcohol.[3]

Breastmilk from a mother who admitted to cocaine use contained cocaine in a concentration of 5 mcg/L. The time of collection and amount of drug use was not stated.[8]

Infant Levels.

A woman who was breastfeeding her 2-week-old daughter reported using about 500 mg of cocaine intranasally over a 4-hour period and breastfeeding 5 times during this period. The infant's urine contained cocaine in a concentration of about 100 mcg/L at 4 and 12 hours after the mother's last cocaine use; the concentration dropped to low levels by 24 hours, but was detectable up to 60 hours after the mother's last dose. The urine benzolyecgonine concentration was over 200 mcg/L at 4 hours post-ingestion and nearly 900 mcg/L at 12 hours post-ingestion. The benzolyecgonine concentration remained near 200 mcg/L until 60 hours post-ingestion when it was undetectable.[6]

A 6-week-old, full-term, breastfed infant was found to have benzoylecgonine in his urine. The infant appeared to be normal but was small for his age. The infant's mother reported using cocaine throughout pregnancy and postpartum.[9]


Effects in Breastfed Infants:


A woman who was breastfeeding her 1-week-old daughter reported using a "dab" of cocaine on her lowergumand nursing her infant with no effect on her infant's behavior or sleep pattern. One week later she used about 500 mg of cocaine intranasally over a 4-hour period and breastfed 5 times during this period. Three hours after first ingesting the cocaine, the mother noted that her infant became markedly irritable, had dilated pupils, and began having vomiting and diarrhea. The infant became increasingly irritable and was taken to the emergency room 4 hours later. On examination, the infant was found to be tremulous and irritable with frequent startling after minimal stimulation, and to have high-pitched crying, hyperactive reflexes, mood lability, and hypertension. The infant also had some signs of fetal alcohol syndrome. The infant remained irritable 12 hours after the last cocaine exposure and remained tremulous and easily startled 24 hours after the last exposure. Irritability and tremulousness slowly abated over the subsequent 24 hours. Mild hypertension persisted up to 72 hours after the last cocaine exposure via breastmilk.[6]

The mother of an 11-day-old infant applied cocaine powder to her nipples for pain relief. She then breastfed her infant using a breast shield that allowed protrusion of her nipples. Three hours later, she found the infant gasping, choking and blue. On arrival at the emergency room, the infant was ashen and cyanotic. He had hypertension, tachycardia, shallow breathing, hypothermia and was in status epilepticus. Seizures resolved in a few hours after treatment and the infant was discharged at 16 days of age with no apparent sequelae.[10] Although the infant's cocaine exposure was not via the drug in breastmilk, it illustrates the extreme risk of exposure of young infants to cocaine.


Possible Effects on Lactation:


Long-term cocaine use can result in chronic, low-level hyperprolactinemia.[11][12][13] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Mothers who use cocaine initiate breastfeeding of their infants less frequently than mothers who do not use cocaine.[14][15]


References:


1. Bateman DA, Heagarty MC. Passive freebase cocaine ('crack') inhalation by infants and toddlers. Am J Dis Child. 1989;143:25-7. PMID:2910042
2. Heidemann SM, Goetting MG. Passive inhalation of cocaine by infants. Henry Ford Hosp Med J. 1990;38: 252-4. PMID:2086554
3. Dickson PH, Lind A, Studts P et al. The routine analysis of breast milk for drugs of abuse in a clinical toxicology laboratory. J Forensic Sci. 1994;39: 207-14. PMID:8113701
4. Bailey DN. Cocaine and cocaethylene binding to human milk. Am J Clin Pathol. 1998;110:491-4. PMID:9763035
5. Sarkar M, Djulus J, Koren G. When a cocaine-using mother wishes to breastfeed: proposed guidelines. Ther Drug Monit. 2005;27:1-2. PMID:15665737
6. Chasnoff IJ, Lewis DE, Squires L. Cocaine intoxication in a breast-fed infant. Pediatrics. 1987;80:836-8. PMID:3684393
7. Winecker RE, Goldberger BA, Tebbett IRet al. Detection of cocaine and its metabolites in breast milk. J Forensic Sci. 2001;46:12221-3. PMID:11569568
8. Marchei E, Escuder D, Pallas CR et al. Simultaneous analysis of frequently used licit and illicit psychoactive drugs in breast milk by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2011;55:309-16. PMID:21330091
9. Shannon M, Lacouture PG, Roa J, Woolf A. Cocaine exposure among children seen at a pediatric hospital. Pediatrics. 1989;83:337-42. PMID:2783999
10. Chaney NE, Franke J, Wadlington WB. Cocaine convulsions in a breast-feeding baby. J Pediatr. 1988;112:134-5. PMID:3335951
11. Mello NK, Mendelson JH. Cocaine's effects on neuroendocrine systems: clinical and preclinical studies. Pharmacol Biochem Behav. 1997;57:571-99. PMID:9218281
12. Elman I, Lukas SE. Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers. Addict Behav. 2005;30:859-64. PMID:15833589
13. Patkar AA, Hill KP, Sterling RC et al. Serum prolactin and response to treatment among cocaine-dependent individuals. Addict Biol. 2002;7:45-53. PMID:11900622
14. Bauer CR, Langer JC, Shankaran S et al. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med. 2005;159:824-34. PMID:16143741
15. England L, Brenner R, Bhaskar B et al. Breastfeeding practices in a cohort of inner-city women: the role of contraindications. BMC Public Health. 2003;3:28. PMID:12930560



Substance Identification:




Substance Name:

Cocaine

CAS Registry Number:

50-36-2

Drug Class:


  • Anesthetics, Local

  • Dopamine Uptake Inhibitors

  • Street Drugs

  • Vasoconstrictor Agents


  • Administrative Information:




    LactMed Record Number:


    694


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.