Creatine

Drug Levels and Effects:




Summary of Use during Lactation:


Creatine is used as a dietary supplement to increase muscle mass and improve exercise performance. Although creatine is a normal component ofhumanmilk, milk levels of creatine have not been measured after exogenous administration in humans. Creatine is converted into creatinine in the mother's and infant's bodies. It may increase the infant's serum creatinine, which may alter estimations of the infant's kidney function.[1] Some authors speculate that creatine supplementation of nursing mothers might help avoid creatine deficiency syndromes, but no studies are available that test this hypothesis.[2] Until more data are available, it is probably best to avoid creatine supplementation unless it is prescribed by a healthcare professional.


Drug Levels:


Milk levels of creatine have not been measured after exogenous administration in humans. Creatine is a normal component ofhumanmilk.

Maternal Levels.

One study found the concentration of creatine to average 25.8 mg/L in normal mothers 3 to 5 days postpartum (n = 3), 18.7 mg/L in mothers 6 to 14 days postpartum (n = 16), and 11.5 mg/L in individual mothers over 15 days postpartum (n = 16). The creatine concentration was 10.1 mg/L in pooled milk from mothers over 15 days postpartum (n = 10).[1]

The creatine concentration in the breastmilk of 3 women was measured. The average concentration was 113 mg/L.[3]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Hulsemann J, Manz F, Wember T, Schoch G. [Administration of creatine and creatinine with breast milk and infant milk preparations]. Klin Padiatr. 1987;199:292-5. PMID:3657037
2. Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 2011;40:1271-96. PMID:21448658
3. Peral MJ, Galvez M, Soria ML, Ilundain AA. Developmental decrease in rat small intestinal creatine uptake. Mech Ageing Dev. 2005;126:523-30. PMID:15722111



Substance Identification:




Substance Name:

Creatine

CAS Registry Number:

57-00-1

Drug Class:


  • Complementary Therapies


  • Administrative Information:




    LactMed Record Number:


    937


    Last Revision Date:


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