Dantrolene

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the long-term use of dantrolene during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. After short-term use, the drug would be expected to be eliminated from milk in 1 to 2 days.


Drug Levels:


Maternal Levels.

Administration of several intravenous dantrolene doses were given over 3 days to a postpartum mother in divided doses. Total daily dosages were 720 mg on day 1, 320 mg on day 2, and 80 mg on day 3. A milk level of 1.2 mg/L was measured on day 2 after a total of 640 mg had been given. The milk level was 50 mcg/L on day 4 about 35 hours after the last dose. Dantrolene half-life in milk was 9.2 hours.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Baclofen


References:


1. Fricker RM, Hoerauf KH, Drewe J et al. Secretion of dantrolene into breast milk after acute therapy of a suspected malignant hyperthermia crisis during cesarean section. Anesthesiology. 1998;89:1023-5. PMID:9778021



Substance Identification:




Substance Name:

Dantrolene

CAS Registry Number:

7261-97-4

Drug Class:


  • Muscle Relaxants, Central


  • Administrative Information:




    LactMed Record Number:


    435


    Last Revision Date:


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