Daptomycin

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that daptomycin produces low levels in milk and it would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.


Drug Levels:


Maternal Levels.

A nursing mother received intravenous daptomycin 500 mg (6.7 mg/kg) andertapenem1 gram once daily for 28 days to treat a pelvic infection. On day 27 of therapy, expressed breastmilk was collected over six 4-hour intervals. Daptomycin milk concentrations were highest in the second sample with a concentration of 44.7 mcg/L. The fifth sample, ending at 20 hours after the dose, contained 29.2 mcg/L of daptomycin and the final sample had no detectable drug (<25 mcg/L).[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Vancomycin


References:


1. Buitrago MI, Crompton JA, Bertolami S et al. Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. Pharmacotherapy. 2009;29:347-51. PMID:19249952



Substance Identification:




Substance Name:

Daptomycin

CAS Registry Number:

103060-53-3

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Peptides, Cyclic

  • Lipopeptides


  • Administrative Information:




    LactMed Record Number:


    708


    Last Revision Date:


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