Drug Levels and Effects:

Summary of Use during Lactation:

Desmopressin is excreted in negligible amounts into milk and is poorly absorbed orally by the infant, so it appears acceptable to use during breastfeeding.

Drug Levels:

Maternal Levels.

In a patient who was using intranasal desmopressin 10 mcg twice daily for diabetes insipidus, serum and milk levels ofargininevasopressin were measured after a dose.[1] Milk levels gradually increased from the background level of 1 ng/L to about 1.5 ng/L over the 4-hour observation period.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Several cases have been reported of mothers with diabetes insipidus using desmopressin and breastfeeding their infants.[2][3] In one case, the mother discontinued nursing after 2 weeks because of a low milk supply, but this was not clearly drug related.[3] Lactation sometimes improves diabetes insipidus and reduces desmopressin requirements.[2][3]


1. Burrow GN, Wassenaar W, Robertson GL et al. DDAVP treatment of diabetes insipidus during pregnacy and the post-partum period. Acta Endocrinol (Copenh). 1981;97:23-5. PMID:7223315
2. Hadi HA, Mashini IS, Devoe LD. Diabetes insipidus during pregnancy complicated by preeclampsia. A case report. J Reprod Med. 1985;30:206-8. PMID:3999072
3. Hime MC, Richardson JA. Diabetes insipidus and pregnancy. Case report, incidence and review of literature. Obstet Gynecol Surv. 1978;33:375-9. PMID:652196

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Hemostatics

  • Vasopressins

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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