Dicloxacillin

Drug Levels and Effects:




Summary of Use during Lactation:


Dicloxacillin is acceptable to use during breastfeeding and is frequently used to treat mastitis in nursing mothers.[1][2] Limited information indicates that dicloxacillin levels in milk are low and are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated.


Drug Levels:


Maternal Levels.

After a single oral dose of 250 mg of dicloxacillin in 2 women, milk levels ranged from 0.2 to 0.3 mg/L between 2 and 4 hours after the dose. The drug was undetectable in milk at 1 and 6 hours after the dose.[3]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Anon. ABM clinical protocol #4: mastitis. Revision, May 2008. Breastfeed Med. 2008;3:177-80. PMID:18778213
2. Berth WL, Schauberger CW, Alvarado MA, Mathiason MA. Telephone-based management of lactation mastitis. J Reprod Med. 2009;54:291-4. PMID:19517693
3. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID:6743732



Substance Identification:




Substance Name:

Dicloxacillin

CAS Registry Number:

3116-76-5

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Penicillins


  • Administrative Information:




    LactMed Record Number:


    90


    Last Revision Date:


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