Drug Levels and Effects:

Summary of Use during Lactation:

Dicyclominehas not been well studied during breastfeeding. However, one possible case of apnea has been reported in a breastfed infant that is similar to reactions that have occurred in infants given the drug directly.[1]Dicyclomineshould not be used during lactation.

Drug Levels:

Maternal Levels.

Relevant published information was not found as of the revision date. However, the manufacturer reported a mother who was given a single 20 mg dose of dicyclomine orally. Two hours after the dose, the concentration in breastmilk was 131 mcg/L.[1]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date. The manufacturer reported a breastfed infant who developed apnea during maternal therapy with dicyclomine .[1]Dicyclomineis a possible cause of the reaction.

Possible Effects on Lactation:

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[2][3][4][5][6] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


1. Briggs GG, Freeman RK, Yaffe SJ . Drugs in pregnancy and lactation, 7 th ed. Baltimore. Williams & Wilkins. 2005.
2. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID:9250502
3. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID:7592071
4. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID:9159285
5. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID:6788407
6. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID:1636447
7. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID:6808052

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Muscarinic Antagonists

  • Parasympatholytics

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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