Diltiazem

Drug Levels and Effects:




Summary of Use during Lactation:


Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.


Drug Levels:


Maternal Levels.

In one patient who was 14 days postpartum, peak milk levels of 190 to 230 mcg/L occurred about 2 hours after the dose during an oral regimen of 60 mg four times daily. The levels and time course of the drug in milk closely paralleled serum levels.[1] Using the peak milk level data from this patient, an exclusively breastfed infant would receive an estimated maximum of 0.9% of the maternal weight-adjusted dosage.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Nifedipine,Verapamil


References:


1. Okada M, Inoue H, Nakamura Y et al. Excretion of diltiazem in human milk. N Engl J Med. 1985;312:992-3. PMID:3974691



Substance Identification:




Substance Name:

Diltiazem

CAS Registry Number:

42399-41-7

Drug Class:


  • Antihypertensive Agents

  • Calcium Channel Blockers

  • Antiarrhythmics

  • Vasodilator Agents


  • Administrative Information:




    LactMed Record Number:


    94


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.