Dobutamine

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of dobutamine during breastfeeding. Because of its poor oral bioavailability and short half-life, any dobutamine in milk is unlikely to affect the infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information in nursing mothers was not found as of the revision date. Unlike dopamine, dobutamine infusion does not affect serum prolactin concentration in infants[1] and in adult males.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Filippi L, Pezzati M, Poggi C et al. Dopamine versus dobutamine in very low birthweight infants: endocrine effects. Arch Dis Child Fetal Neonatal Ed. 2007;92:F367-71. PMID:17329276
2. Schilling T, Grundling M, Strang CM. Effects of dopexamine, dobutamine or dopamine on prolactin and thyreotropin serum concentrations in high-risk surgical patients. Intensive Care Med. 2004;30:1127-33. PMID:15138671



Substance Identification:




Substance Name:

Dobutamine

CAS Registry Number:

34368-04-2

Drug Class:


  • Adrenergic beta-Agonists

  • Cardiotonic Agents

  • Catecholamines

  • Sympathomimetics


  • Administrative Information:




    LactMed Record Number:


    747


    Last Revision Date:


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