Docusate

Drug Levels and Effects:




Summary of Use during Lactation:


Docusate is minimally absorbed from the gastrointestinal tract and therefore the drug is unlikely to be found in the maternal serum or breastmilk. Laxatives that are completely unabsorbed may be preferred.[2]


Drug Levels:


Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


In a randomized, blinded trial, 35 postpartum breastfeeding patients received a laxative containing docusate in a dose of 120 mg daily in addition to danthron 100 mg daily. One patient stated that diarrhea occurred in her breastfed infant.[1] The diarrhea was most likely caused by the danthron.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Bisacodyl,Magnesium Hydroxide,Psyllium,Senna


References:


1. Greenhalf JO, Leonard HS. Laxatives in the treatment of constipation in pregnant and breast-feeding mothers. Practitioner. 1973;210:259-63. PMID:4570522
2. Lewis JH, Weingold AB and the Committee of FDA-Related Matters, American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912-23. PMID:2864852



Substance Identification:




Substance Name:

Docusate

CAS Registry Number:

10041-19-7

Drug Class:


  • Gastrointestinal Agents

  • Laxatives

  • Surface-Active Agents


  • Administrative Information:




    LactMed Record Number:


    456


    Last Revision Date:


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