Dopamine

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of dopamine during breastfeeding. Because of its poor oral bioavailability and short half-life, any dopamine in milk is unlikely to affect the infant. Intravenous dopamine infusion may decrease milk production.Dopamineis known to reduce serum prolactin in nonnursing women, but no information is available on its effect on milk production in nursing mothers.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Intravenous dopamine infusion in doses of 2 to 5 mcg/kg/minute given to nonnursing subjects and in women with hyperprolactinemia decreases serum prolactin concentrations.[1][2][3][4][5] However, relevant published information on the effect of intravenous dopamine on milk production in nursing mothers was not found as of the revision date. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Judd SJ, Rigg LA, Yen SS. The effects of ovariectomy and estrogen treatment on the dopamine inhibition of gonadotropin and prolactin release. J Clin Endocrinol Metab. 1979;49:182-4. PMID:572372
2. Massara F, Camanni F, Vergano V et al. Inhibition of thyrotropin and prolactin secretion by dopamine in man. J Endocrinol Invest. 1978;1:25-30. PMID:573767
3. Nicoletti I, Filipponi P, Sfrappini M et al. Catecholamines and pituitary function. I. Effects of catecholamine synthesis inhibition and subsequent catecholamine infusion on gonadotropin and prolactin serum levels in normal cycling women and in women with hyperprolactinemic amenorrhea. Horm Res. 1984;19:158-70. PMID:6425187
4. Leblanc H, Lachelin GC, Abu-Fadil S, Yen SS. Effects of dopamine infusion on pituitary hormone secretion in humans. J Clin Endocrinol Metab . 1976;43:668-74. PMID:956350
5. Crosignani PG , Reschini E, Peracchi M et al. Failure of dopamine infusion to suppress the plasma prolactin response to sulpiride in normal and hyperprolactinemic subjects. J Clin Endocrinol Metab. 1977;45:841-4. PMID:410826



Substance Identification:




Substance Name:

Dopamine

CAS Registry Number:

51-61-6

Drug Class:


  • Cardiotonic Agents

  • Catecholamines

  • Dopamine
  • Agents

  • Sympathomimetics


  • Administrative Information:




    LactMed Record Number:


    741


    Last Revision Date:


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