Droperidol

Drug Levels and Effects:




Summary of Use during Lactation:


Because little information is available on the long-term use of droperidol during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Single-dose or short-term use during breastfeeding, such as during surgery, is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months.[1] When multiple doses are given to the mother, monitor the infant for drowsiness, especially in younger, exclusively breastfed infants and when using combinations of psychotropic drugs.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


One breastfed (extent not stated) infant whose mother was taking droperidol had a somewhat decreased intellectual development on testing, but her mother had also taken olanzapine, clonazepam, sertraline, thioridazine andvalproicacidwhile breastfeeding.[2]


Possible Effects on Lactation:


Hyperprolactinemia has been reported in patients taking long-term droperidol.[3] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994;38:94-103. PMID:8171959
2. Gardiner SJ, Kristensen JH, Begg EJ et al. Transfer of olanzapine in to breast milk, calculation of infant drug dose, and effect on breast-fed infants. Am J Psychiatry. 2003;160:1428-31. PMID:12900304
3. Langer G, Puhringer W. Haloperidol and droperidol treatment in schizophrenics. Clinical application of the "prolactin-model". Acta Psychiatr Belg. 1980;80:574-83. PMID:7234451
4. Smith S, Wheeler MJ, Murray R, O'Keane V. The effects of antipsychotic-induced hyperprolactinaemia on the hypothalamic-pituitary-gonadal axis. J Clin Psychopharmacol. 2002;22:109-14. PMID:11910254
5. Naito Y, Tamai S, Fukata J et al. Comparison of endocrinological stress response associated with transvaginal ultrasound-guided oocyte pick-up under halothane anaesthesia and neuroleptanaesthesia. Can J Anaesth. 1989;36:633-6. PMID:2555076
6. Jullien Y, de Rodez M, Bonardet A et al. [Comparison of postoperative blood levels of prolactin and somatotropin after two methods of anesthesia]. Ann Anesthesiol Fr. 1980;21:459-66. PMID:6110401



Substance Identification:




Substance Name:

Droperidol

CAS Registry Number:

548-73-2

Drug Class:


  • Antiemetics

  • Antipsychotic Agents

  • Butyrophenones

  • Dopamine Antagonists


  • Administrative Information:




    LactMed Record Number:


    707


    Last Revision Date:


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