Drug Levels and Effects:

Summary of Use during Lactation:

Because little information is available on the long-term use of droperidol during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Single-dose or short-term use during breastfeeding, such as during surgery, is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months.[1] When multiple doses are given to the mother, monitor the infant for drowsiness, especially in younger, exclusively breastfed infants and when using combinations of psychotropic drugs.

Drug Levels:

Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

One breastfed (extent not stated) infant whose mother was taking droperidol had a somewhat decreased intellectual development on testing, but her mother had also taken olanzapine, clonazepam, sertraline, thioridazine andvalproicacidwhile breastfeeding.[2]

Possible Effects on Lactation:

Hyperprolactinemia has been reported in patients taking long-term droperidol.[3] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.


1. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994;38:94-103. PMID:8171959
2. Gardiner SJ, Kristensen JH, Begg EJ et al. Transfer of olanzapine in to breast milk, calculation of infant drug dose, and effect on breast-fed infants. Am J Psychiatry. 2003;160:1428-31. PMID:12900304
3. Langer G, Puhringer W. Haloperidol and droperidol treatment in schizophrenics. Clinical application of the "prolactin-model". Acta Psychiatr Belg. 1980;80:574-83. PMID:7234451
4. Smith S, Wheeler MJ, Murray R, O'Keane V. The effects of antipsychotic-induced hyperprolactinaemia on the hypothalamic-pituitary-gonadal axis. J Clin Psychopharmacol. 2002;22:109-14. PMID:11910254
5. Naito Y, Tamai S, Fukata J et al. Comparison of endocrinological stress response associated with transvaginal ultrasound-guided oocyte pick-up under halothane anaesthesia and neuroleptanaesthesia. Can J Anaesth. 1989;36:633-6. PMID:2555076
6. Jullien Y, de Rodez M, Bonardet A et al. [Comparison of postoperative blood levels of prolactin and somatotropin after two methods of anesthesia]. Ann Anesthesiol Fr. 1980;21:459-66. PMID:6110401

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Antiemetics

  • Antipsychotic Agents

  • Butyrophenones

  • Dopamine Antagonists

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.