Drospirenone

Drug Levels and Effects:




Summary of Use during Lactation:


Drospirenone is a progestin that is an analogue of spironolactone. It has antimineralocorticoid and antiandrogenic activities and is available in the US only in combination withethinylestradiolas an oral contraceptive agent. Based on the available evidence, expert opinion holds that nonhormonal methods are preferred during breastfeeding and progestin-only contraceptive are preferred over combined oral contraceptives in breastfeeding women, especially during the first 4 weeks postpartum. For further information, consult the record entitled, "Contraceptives, Oral, Combined."


Drug Levels:


Maternal Levels.

Six women who were between 1 week and 3 months postpartum received a single dose of drospirenone 3 mg plusethinylestradiol30 mcg. Milk was collected for 72 hours after the dose in 2 of the women in whom half-lives in breastmilk were 8.3 and 15.5 hours. The average peak milk level in the 6 women was 13.5 mcg/L at 2.8 hours after the dose. The average drospirenone milk level in the first 24 hours was 3.7 mcg/L (range 1.4 to 7 mcg/L). The authors estimated that a fully breastfed infant would receive a drospirenone dose of about 3 mcg daily.[1] Using the average serum level data, an exclusively breastfed infant would receive 1.1% of the weight-adjusted maternal dosage of drospirenone.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Etonogestrel,Levonorgestrel,Medroxyprogesterone Acetate,Norethindrone


References:


1. Blode H, Foidart JM, Heithecker R. Transfer of drospirenone to breast milk after a single oral administration of 3 mg drospirenone + 30 mcg ethinylestradiol to healthy lactating women. Eur J Contracept Reprod Health Care. 2001;6:167-71. PMID:11763981



Substance Identification:




Substance Name:

Drospirenone

CAS Registry Number:

67392-87-4

Drug Class:


  • Aldosterone Antagonists

  • Contraceptive Agents, Female

  • Contraceptives, Oral, Synthetic


  • Administrative Information:




    LactMed Record Number:


    480


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.