Dyphylline

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the relatively high levels in milk and a previous report with theophylline, occasional stimulant effects in infants should be anticipated in breastfed infants. No severe adverse reactions are expected. Amounts in milk can be minimized by avoiding breastfeeding for 3 to 4 hours after a dose.


Drug Levels:


Maternal Levels.

After intramuscular administration of a single 5 mg/kg dose of dyphylline, peak milk levels usually occurred between 2 and 4 hours after the dose in 20 subjects. Peak milk levels averaged 24.3 mg/L.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Albuterol,Aminophylline,Theophylline


References:


1. Jarboe CH, Cook LN, Malesic I, Fleischaker J. Dyphylline elimination kinetics in lactating women: blood to milk transfer. J Clin Pharmacol. 1981;21:405-10. PMID:7309903



Substance Identification:




Substance Name:

Dyphylline

CAS Registry Number:

479-18-5

Drug Class:


  • Anti-Asthmatic Agents

  • Bronchodilators


  • Administrative Information:




    LactMed Record Number:


    590


    Last Revision Date:


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