Echothiophate

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of echothiophate ophthalmic drops during breastfeeding. Because echothiophate is a quaternaryammoniumcompound, it is not likely to pass into the breastmilk or reach the bloodstream of the infant.[1]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001;45:449-54. PMID:11274697
2. Clarke G, Fall CH, Lincoln DW, Merrick LP. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin. Br J Pharmacol. 1978;63:519-27. PMID:566601
3. Muller EE, Locatelli V, Cella S et al. Prolactin-lowering and -releasing drugs: mechanisms of action and therapeutic applications. Drugs. 1983;25:399-432. PMID:6133737



Substance Identification:




Substance Name:

Echothiophate

CAS Registry Number:

513-10-0

Drug Class:


  • Cholinesterase Inhibitors

  • Miotics

  • Parasympathomimetics


  • Administrative Information:




    LactMed Record Number:


    753


    Last Revision Date:


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