Eculizumab

Drug Levels and Effects:




Summary of Use during Lactation:


Information from one patient indicates that a maternal dose of eculizumab of 900 mg every 12 days produced undetectable levels in breastmilk. If eculizumab is required by the mother, it is not a reason to discontinue breastfeeding. However, until more data are available, eculizumab should only be used with careful monitoring during breastfeeding.


Drug Levels:


Maternal Levels.

One woman with paroxysmal nocturnal hemoglobinuria had received eculizumab for 5 years before becoming pregnant. She continued to receive the drug during pregnancy at a dosage of 900 mg every 12 days and postpartum. At delivery, she had a therapeutic eculizumab serum concentration of 116.1 mg/L. Breastmilk samples taken on days 1, 2, 3, 9 and 10 after delivery contained no detectable drug (lower limit of assay and time of last dose not stated).[1][2]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Kelly R, Arnold LM, Richards SJ, Hill A, Bomken C, Hanley J et al. Successful pregnancy outcome in paroxysmal nocturnal haemoglobinuria on long term eculizumab . Haematologica. 2009;94 (Suppl. 2):452. Abstract.
2. Kelly R, Arnold L, Richards S, Hill A, Bomken C, Hanley J et al. The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab . Br J Haematol. 2010;149:446-50. PMID:20151973



Substance Identification:




Substance Name:

Eculizumab

CAS Registry Number:

219685-50-4

Drug Class:


  • Antibodies, Monoclonal, Humanized


  • Administrative Information:




    LactMed Record Number:


    999


    Last Revision Date:


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