Estradiol Cypionate

Drug Levels and Effects:




Summary of Use during Lactation:


Estradiol cypionate has not been studied during breastfeeding. However, the similar drug, estradiolvalerate, has been used to suppress lactation, usually in combination with testosterone. Generally, estradiol cypionate should be avoided in mothers wishing to breastfeed.


Drug Levels:


Maternal Levels.

Relevant published information on estradiol cypionate was not found as of the revision date. However, estradiol appears in breastmilk in small amounts after administration by other routes.[1][2]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Another injection ester form of estradiol, estradiolvaleratewas previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]

A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]


Alternate Drugs to Consider:


Ethinyl Estradiol


References:


1. Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol in human milk. Am J Obstet Gynecol. 1978;132:653-7 . PMID:717472
2. Perheentupa A, Critchley HO, Illingworth PJ, McNeilley AS. Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000;85:4280-6. PMID:11095468
3. Louviere RL, Upton RT. Evaluation of Deladumone OB in the suppression of postpartum lactation. Am J Obstet Gynecol. 1975;121:641-2. PMID:1090174
4. Morris JA, Creasy RK, Hohe PT. Inhibition of puerperal lactation. Double-blind comparison of chlorotrianesene, testosterone enanthate with estradiolvalerateand placebo. Obstet Gynecol. 1970;36:107-14. PMID:4912251
5. Iliya FA, Safon L, O'Leary JA. Testosterone enanthate (180 mg.) and estradiolvalerate(8 mg.) for suppression of lactation: a double-blind evaluation. Obstet Gynecol. 1966;27:643-5. PMID:5949195
6. Jordan HL, Bruinsma FJ, Thomson RJ et al. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007;24:397-402. PMID:17531440



Substance Identification:




Substance Name:

Estradiol Cypionate

CAS Registry Number:

313-06-4

Drug Class:


  • Estrogens

  • Hormones


  • Administrative Information:




    LactMed Record Number:


    852


    Last Revision Date:


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