Fenoprofen

Drug Levels and Effects:




Summary of Use during Lactation:


Some reviewers consider fenoprofen to be acceptable during breastfeeding.[1] Because there is little published experience with fenoprofen during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date. Data are limited to those reported in a review article by the drug's manufacturer in which no study details are reported. After a dose of 600 mg every 6 hours for 4 days in postpartum mothers, breastmilk fenoprofen levels were reportedly 1.6% of those in maternal plasma and below those accurately detected by the assay (assay limit not stated).[2] Additionally, fenoprofen has glucuronide metabolites that could be absorbed as fenoprofen by a newborn.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acetaminophen,Flurbiprofen,Ibuprofen,Indomethacin,Naproxen,Piroxicam


References:


1. Brooks PM, Needs CJ. Antirheumatic drugs in pregnancy and lactation. Baillieres Clin Rheumatol. 1990;4:157-71. PMID:2282661
2. Rubin A, Chernish SM, Crabtree R et al. A profile of the physiological disposition and gastro-intestinal effects of fenoprofen in man. Curr Med Res Opin. 1974;2:529-44. PMID:4615886



Substance Identification:




Substance Name:

Fenoprofen

CAS Registry Number:

31879-05-7

Drug Class:


  • Analgesic Agents

  • Nonsteroidal Antiinflammatory Agents


  • Administrative Information:




    LactMed Record Number:


    110


    Last Revision Date:


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