Flurazepam

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the excretion of flurazepam into breastmilk. One case of infant sedation was reported in a woman taking flurazepam along with other sedating drugs during breastfeeding. Because of the long duration of action of flurazepam, an alternate hypnotic is preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. One mother who was taking flurazepam (dose unclear), clonazepam 0.25 mg twice daily, 1 mg ofbupropiondaily, and 0.75 mg of risperidone daily reported sedation in her breastfed infant.[1]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Zaleplon,Zolpidem


References:


1. Kelly LE, Poon S, Madadi P, Koren G. Neonatal benzodiazepines exposure during breastfeeding. J Pediatr. 2012;161:448-51. PMID:22504099



Substance Identification:




Substance Name:

Flurazepam

CAS Registry Number:

17617-23-1

Drug Class:


  • Benzodiazepines

  • Hypnotics and Sedatives


  • Administrative Information:




    LactMed Record Number:


    820


    Last Revision Date:


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