Flurbiprofen

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the low levels of flurbiprofen in breastmilk and its short half-life it is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months. Maternal use of flurbiprofen eye drops would not be expected to cause any adverse effects in breastfed infants.


Drug Levels:


Maternal Levels.

Ten women who were at least 1 month postpartum were given a single 100 mg tablet of flurbiprofen. Flurbiprofen was undetectable (<70 mcg/L) in the milk of 5 of the women. In the remaining 5 women, an average peak milk level of 92 mcg/L occurred at about 3 hours after the dose. Flurbiprofen was undetectable in any mother's milk by 24 hours after the dose.[1] Using data from this study, a fully breastfed infant would ingest an estimated maximum of 2.2 mcg/kg/day after this maternal dosage or about 0.1% of the maternal weight-adjusted dosage.

Twelve women who were 3 to 5 days postpartum received flurbiprofen 50 mg orally four times a day for 9 doses over 3 days. Milk samples were collected at various unspecified times during this regimen. Flurbiprofen was undetectable (<50 mcg/L) in all but 3 milk samples. One woman had levels of 70 mcg/L 1 hour after her first dose and 60 mcg/L just before her second dose. Another woman had a milk flurbiprofen concentration of 80 mcg/L 2 hours after her last dose. The authors estimated that the maximum dose that a completely breastfed infant would ingest is less than 0.5% of the maternal weight-adjusted dosage.[2]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acetaminophen,Ibuprofen,Indomethacin,Naproxen,Piroxicam


References:


1. Cox SR, Forbes KK. Excretion of flurbiprofen into breast milk. Pharmacotherapy. 1987;7:211-5. PMID:3444752
2. Smith IJ, Hinson JL, Johnson VA et al. Flurbiprofen in post-partum women: plasma and breast milk disposition. J Clin Pharmacol. 1989;29:174-84. PMID:2715375



Substance Identification:




Substance Name:

Flurbiprofen

CAS Registry Number:

5104-49-4

Drug Class:


  • Analgesic Agents

  • Nonsteroidal Antiinflammatory Agents


  • Administrative Information:




    LactMed Record Number:


    118


    Last Revision Date:


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