Fosfomycin

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that fosfomycin produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.


Drug Levels:


Maternal Levels.

After 1 to 2 grams of fosfomycin given by injection, colostrum levels in 2 women were 4.8 mg/L and milk levels were 3.6 mg/L.[1][2] Further details of the studies were not given.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Nitrofurantoin,Norfloxacin,Trimethoprim


References:


1. Gallego A, Rodriguez A, Mata A. Fosfomycin: pharmacological studies. Drugs Today (Barc). 1974;10 (Suppl):161-8.
2. Kirby WMM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977;23 (Suppl 1):141-51. PMID:832510



Substance Identification:




Substance Name:

Fosfomycin

CAS Registry Number:

23155-02-4

Drug Class:


  • Antibacterial Agents

  • Antiinfective Agents, Urinary


  • Administrative Information:




    LactMed Record Number:


    478


    Last Revision Date:


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