Gadoteridol

Drug Levels and Effects:




Summary of Use during Lactation:


Although early investigators recommended withholding breastfeeding following administration of gadolinium contrast agents, a more recent and much larger study on another agent, gadopentetate, indicated that the amounts of gadolinium excreted into breastmilk are less than 1% of the amount allowed to be given to infants. In addition, because gadolinium contrast agents are poorly absorbed orally, none is likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium.[1][2][3] However, because there is no published experience with gadoteridol during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Gadopentetate


References:


1. American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2012;Version 8:79-80.
2. Webb JA, Thomsen HS, Morcos SK et al. The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005;15:1234-40. PMID:15609057
3. Chen MM, Coakley FV, Kaimal A, Laros RK Jr. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol. 2008;112:333-40. PMID:18669732



Substance Identification:




Substance Name:

Gadoteridol

CAS Registry Number:

112188-16-6

Drug Class:


  • Contrast Media

  • Diagnostic Agents


  • Administrative Information:




    LactMed Record Number:


    533


    Last Revision Date:


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