Glipizide

Drug Levels and Effects:




Summary of Use during Lactation:


Limited data indicate that the levels of glipizide in milk are low. However, an alternate drug for which there is more information may be preferred, especially while nursing a newborn or preterm infant. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]


Drug Levels:


Two women who had delivered via cesarean section and were receiving glipizide 5 mg daily in the immediate postoperative period had milk glipizide levels measured. Trough glipizide milk levels were undetectable (<80 mcg/L). The authors estimated that the maximum dosages that a fully breastfed infant would receive is <27 %="" of="" the="" weight-adjusted="" maternal="">


Effects in Breastfed Infants:


Blood glucose levels were normal in 2 breastfed infants whose mothers were taking oral glipizide 5 mg daily.[3]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acarbose,Chlorpropamide,Glyburide,Insulin,Metformin,Tolbutamide


References:


1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID:9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID:15701580
3. Feig DS, Briggs GG, Kraemer JM et al. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005;28:1851-5. PMID:16043722



Substance Identification:




Substance Name:

Glipizide

CAS Registry Number:

29094-61-9

Drug Class:


  • Hypoglycemic Agents

  • Sulfonylurea Compounds


  • Administrative Information:




    LactMed Record Number:


    127


    Last Revision Date:


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