Glyburide

Drug Levels and Effects:




Summary of Use during Lactation:


Limited data indicate that the levels of glyburide in milk are negligible. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]


Drug Levels:


Maternal Levels.

Eight women who had recently delivered were given a single dose of glyburide 5 mg (n = 6) or 10 mg (n = 2) orally. Glyburide was undetectable (<5 mcg/L) in milk at 2, 4, 6 and 8 hours after the dose. The authors estimated that the maximum dosages that a fully breastfed infant would receive with the 5 and 10 mg doses are <1.5% and=""><0.7% of="" the="" maternal="" weight-adjusted="" dosage,="">

In a separate study reported in the same paper, 3 women who had delivered via cesarean section and were receiving glyburide 5 mg daily in the immediate postoperative period had milk glyburide levels measured. Trough glyburide milk levels were undetectable (<80 mcg/L).[3]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


The blood glucose level was normal in one breastfed infant whose mothers was taking oral glyburide 5 mg daily.[3]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acarbose,Chlorpropamide,Insulin,Metformin,Tolbutamide


References:


3. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID:9429368
4. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID:15701580
1. Feig DS, Briggs GG, Kraemer JM et al. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005;28:1851-5. PMID:16043722
2. Feig DS, Kraemer JM, Moskovitz DN et al. The transfer of glyburide into breast milk. Clin Pharmacol Ther. 2004;75(2):P24. Abstract.



Substance Identification:




Substance Name:

Glyburide

CAS Registry Number:

10238-21-8

Drug Class:


  • Hypoglycemic Agents

  • Sulfonylurea Compounds


  • Administrative Information:




    LactMed Record Number:


    128


    Last Revision Date:


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