Guanfacine

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of guanfacine during breastfeeding and its possible negative effects on lactation, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Published information on the effects of guanfacine on serum prolactin or on lactation in nursing mothers was not found as of the revision date. Guanfacine decreases basal serum prolactin in men and nonnursing women. Serum prolactin continues to decrease for at least 7 years during continuous use.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Enalapril,Hydrochlorothiazide,Methyldopa,Propranolol


References:


1. Hauger-Klevene JH, Balossi EC, Scornavacchi JC. Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension. Am J Cardiol. 1986;57:27E-31E. PMID:3513527



Substance Identification:




Substance Name:

Guanfacine

CAS Registry Number:

29110-47-2

Drug Class:


  • Antihypertensive Agents

  • Adrenergic alpha-Agonists


  • Administrative Information:




    LactMed Record Number:


    631


    Last Revision Date:


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