Haemophilus Vaccines

Drug Levels and Effects:




Summary of Use during Lactation:


Although there is some conflicting information on the effect of breastfeeding on infants' antibody response to

Haemophilus influenzae

typebvaccines, there is no evidence that breastfeeding reduces protection against the disease. The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to the

Haemophilus influenzae

vaccine.[1][2][3]

Breastfeeding alone appears to increase antibodies against

Haemophilus influenzae

and reduce the incidence of

Haemophilus influenzae

typebmeningitis.[4][5][6] Breastfeeding also appears to reduce infant side effects associated with routine childhood immunization. Breastfed infants should be vaccinated according to the routine recommended schedules.


Drug Levels:


Maternal Levels.

A study compared colostrum and milk antibody levels following maternal immunization with

Haemophilus influenzae

typebpolysaccharide vaccine at 3 time periods. Women who were immunized at 24 to 26 weeks of pregnancy had higher antibody levels in colostrum (average 21 mg/L) and in breastmilk at 3 or 6 months after delivery (average 3.1 mg/L) than women who were immunized 1 to 8 months before pregnancy (average 0.13 mg/L at 3 or 6 months postpartum) or those who had not been immunized (average 0.91 mg/L in colostrum, and 0.09 mg/L at 3 or 6 months postpartum).[7]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Breastfed infants are less likely to have fever[8] and may be less likely to experience anorexia and reduced energy intake[9] after routine childhood immunization than those who are not breastfed.

In 2 studies, breastfed infants had higher antibody titers against

Haemophilus influenzae

typebthan formula-fed infants at 7 and 12 months of age after vaccination with a

Haemophilus influenzae

typebconjugate vaccine.[1][10] In another study, infants breastfed for longer than 90 days had a better antibody response to the vaccine at 13 months of age than those breastfed less than 90 days.[11]

In a study of 408 infants immunized with

Haemophilus influenzae

typebpolysaccharide-tetanus toxoid conjugate vaccine, no difference in antibody titer was observed at 7 months between infants breastfed for less than 4 weeks and those who were breastfed for 24 weeks or more. Likewise, no difference in antibody response was found when infants were grouped by breastfeeding less than 1 month or greater than 1 month.[12] Another study of 252 infants who each received one of 4

Haemophilus influenzae

typebvaccines found no difference in antibody titers among those who were breastfed and those who were not.[13]

Among 272 infants who were vaccinated with Hib PRP-OMP vaccine at 2 and 4 months postpartum, 101 were breastfed and 171 were formula fed. Of the breastfed infants, 79% were breastfed at least 80% at 7 weeks and 59% at 7 months of age. Breastfed infants had lower IgG titers than formula-fed infants at both 7 weeks and 7 months of age. Although the difference was statistically significant after adjustment for confounding variables, no invasive

Haemophilus influenzae

typebinfections occurred in any of the infants in the study.[14]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60 (RR-2):1-64. PMID:21293327
2. Gruslin A, Steben M, Halperin S et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187-91. PMID:19367691
3. Anon. Human milk. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
4. Silfverdal SA , Bodin L, Ulanova M et al. Expression of idiotypic antibodies-1 and -2 and breastfeeding in relation to antibody levels against Haemophilus influenzae typebin children. Scand J Immunol. 2006;63:371-5. PMID:16640661
5. Silfverdal SA , Bodin L, Olcen P. Protective effect of breastfeeding: an ecologic study of Haemophilus influenzae meningitis and breastfeeding in a Swedish population. Int J Epidemiol. 1999;28:152-6. PMID:10195681
6. Silfverdal SA, Bodin L, Hugosson S et al. Protective effect of breastfeeding on invasive Haemophilus influenzae infection: a case-control study in Swedish preschool children. Int J Epidemiol. 1997;26:443-50. PMID:9169183
7. Insel RA, Amstey M, Pichichero ME. Postimmunization antibody to the Haemophilus influenzae typebcapsule in breast milk. J Infect Dis. 1985;152:407-8. PMID:3875665
8. Pisacane A, Continisio P, Palma O et al. Breastfeeding and risk for fever after immunization. Pediatrics. 2010;125:e1448-52. PMID:20478932
9. Lopez-Alarcon M, Garza C, Habicht JP et al. Breastfeeding attenuates reductions in energy intake induced by a mild immunologic stimulus represented by DPTH immunization: possible roles of interleukin-1beta, tumor necrosis factor-alpha and leptin. J Nutr. 2002;132:1293-8. PMID:12042449
10. Pabst HF, Spady DW. Effect of breast-feeding on antibody response to conjugate vaccine. Lancet. 1990;336:269-70. PMID:1973970
11. Silfverdal SA , Ekholm L, Bodin L. Breastfeeding enhances the antibody response to Hib and pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines. Vaccine. 2006;25:1497-502. PMID:17097198
12. Scheifele D, Bjornson GJ, Guasparini R et al. Breastfeeding and antibody responses to routine vaccination in infants. Lancet. 1992;340:1406. PMID:1360102
13. Decker MD, Edwards KM, Bradley R, Palmer P. Comparative trial in infants of four conjugate haemophilus influenzae typebvaccines. J Pediatr. 1992;120:184-9. PMID:1735812
14. Hawkes JS , Makrides M , Roberton DM , Gibson RA . Responses to immunisation with Hib conjugate vaccine in Australian breastfed and formula-fed infants. J Paediatr Child Health. 2007;43:597-600. PMID:17688643



Substance Identification:




Substance Name:

Haemophilus Vaccines

Drug Class:


  • Vaccines


  • Administrative Information:




    LactMed Record Number:


    130


    Last Revision Date:


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