Hepatitis B Vaccine

Drug Levels and Effects:

Summary of Use during Lactation:

The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to the hepatitisBvaccine. Additionally, hepatitisBvaccine is safely administered directly to newborn infants. Breastfeeding also appears to reduce infant side effects associated with routine childhood immunization. Breastfed infants should be vaccinated according to the routine recommended schedules.[1][2][3]

Drug Levels:

Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Breastfeeding can enhance the response of the infant to certain vaccine antigens.[1][3][4] Breastfed infants are also less likely to have fever[5] and may be less likely to experience anorexia and reduced energy intake[6] after routine childhood immunization than those who are not breastfed.

Breastfed infants of hepatitisBsurface antigen positive mothers have a different response in the development of immunoglobulin subtypes after vaccination with hepatitisBvaccine than do formula-fed infants.[7] However, breastfeeding does not interfere with the infant's antibody response to hepatitisBvaccine.[8]

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.


1. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60 (RR-2):1-64. PMID:21293327
2. Gruslin A, Steben M, Halperin S et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187-91. PMID:19367691
3. Anon. Human milk. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
4. Pabst HF. Immunomodulation by breast-feeding. Pediatr Infect Dis J. 1997;16:991-5. PMID:9380478
5. Pisacane A, Continisio P, Palma O et al. Breastfeeding and risk for fever after immunization. Pediatrics. 2010;125:e1448-52. PMID:20478932
6. Lopez-Alarcon M, Garza C, Habicht JP et al. Breastfeeding attenuates reductions in energy intake induced by a mild immunologic stimulus represented by DPTH immunization: possible roles of interleukin-1beta, tumor necrosis factor-alpha and leptin. J Nutr. 2002;132:1293-8. PMID:12042449
7. Azzari C, Resti M, Rossi ME et al. Modulation by human milk of IgG subclass response to hepatitisBvaccine in infants. J Pediatr Gastroenterol Nutr. 1990;10:310-5. PMID:2324890
8. Wang JS, Zhu QR, Wang XH. Breastfeeding does not pose any additional risk of immunoprophylaxis failure on infants of HBV carrier mothers. Int J Clin Pract. 2003;57(2):100-2. PMID:12661791

Substance Identification:

Substance Name:


Drug Class:

  • Vaccines

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.