Human Papillomavirus Vaccines

Drug Levels and Effects:




Summary of Use during Lactation:


The Centers for Disease Control and Prevention and the several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants.[1][2][3][4][5] A slightly higher percentage of infants who were breastfed during or after maternal vaccination with the active quadrivalenthumanpapillomavirus vaccine (Gardasil) had pneumonia during the 30 days after maternal vaccination, but these effects were not thought to be vaccine related. No similar data exist for the bivalent vaccine (Cervarix). Maternal vaccination withhumanpapillomavirus vaccine is not a contraindication to breastfeeding.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


A total of 995 nursing mothers were given Gardasil or placebo during the vaccination period of the clinical trials (vaccine n = 500, control n = 495). A total of 17 (3.4%) and nine (1.8%) infants of women who breastfed who received quadrivalent HPV vaccine or placebo, respectively, experienced a serious adverse event. Of the 23 experiences among the 17 infants of women who received vaccine, 12 were respiratory infections, five were gastroenteritis or diarrhea, and the remaining included various other single events. None of the reactions was considered vaccine related.[6][7]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60 (RR-2):1-64. PMID:21293327
2. Harpaz R, Ortega-Sanchez IR, Seward JF. Prevention of Herpes zoster: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep. 2008;57 (RR-5):1-30. PMID:18528318
3. Gruslin A, Steben M, Halperin S et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187-91. PMID:19367691
4. Anon.Humanmilk. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
5. Committee opinion no. 467:humanpapillomavirus vaccination. Obstet Gynecol. 2010;116:800-3. PMID:20733476
6. Markowitz LE, Dunne EF, Saraiya M et al. Quadrivalenthumanpapillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56 (RR-2):1-24. PMID:17380109
7. Garland SM, Ault KA, Gall SA et al. Pregnancy and infant outcomes in the clinical trials of ahumanpapillomavirus type 6/11/16/18 vaccine: a combined analysis of five randomized controlled trials. Obstet Gynecol. 2009;114:1179-88. PMID:19935017



Substance Identification:




Substance Name:

HumanPapillomavirus Vaccines

Drug Class:


  • Vaccines


  • Administrative Information:




    LactMed Record Number:


    800


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.