Hydroxyurea

Drug Levels and Effects:




Summary of Use during Lactation:


Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.


Drug Levels:


Maternal Levels.

A mother was taking 500 mg of hydroxyurea orally three times a day. Milk samples taken 2 hours after the last dose of each day on 3 days averaged 6.1 mg/L (range 3.8 to 8.4 mg/L). Using these data, the infant in this case would have received less than 4% of maternal weight-adjusted dosage.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Dependent on the condition being treated.


References:


1. Sylvester RK, Lobell M, Teresi ME et al. Excretion of hydroxyurea into milk. Cancer. 1987;60:2177-8. PMID:3481556



Substance Identification:




Substance Name:

Hydroxyurea

CAS Registry Number:

127-07-1

Drug Class:


  • Antineoplastic Agents


  • Administrative Information:




    LactMed Record Number:


    140


    Last Revision Date:


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