Drug Levels and Effects:

Summary of Use during Lactation:

Because of the low levels of ketoprofen in breastmilk and its short half-life, it is unlikely to adversely affect the breastfed infant. However, because there is no published experience with breastfeeding during ketoprofen use, other agents may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels:

Maternal Levels.

Eighteen women were given ketoprofen 100 mg every 12 hours (average 2.69 mg/kg daily) intravenously for 2 to 3 days postpartum. One to 4 milk samples were collected between the 3rd and 4th dose of ketoprofen. Of the 61 samples collected, ketoprofen was undetectable (<20 mcg/L) in 17 of the samples. The authors assumed a milk concentration of 20 mcg/L for undetectable samples and calculated an average milk concentration of 57 mcg/L (range 20 to 177 mcg/L). A fully breastfed infant would receive an average dosage of 8.5 mcg/kg daily or 0.31% of the maternal weight-adjusted dosage.[1]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider:



1. Jacqz-Aigrain E, Serreau R, Boissinot C et al. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007;29:815-8. PMID:18043481

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Analgesic Agents

  • Nonsteroidal Antiinflammatory Agents

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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