Ketoprofen

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the low levels of ketoprofen in breastmilk and its short half-life, it is unlikely to adversely affect the breastfed infant. However, because there is no published experience with breastfeeding during ketoprofen use, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Eighteen women were given ketoprofen 100 mg every 12 hours (average 2.69 mg/kg daily) intravenously for 2 to 3 days postpartum. One to 4 milk samples were collected between the 3rd and 4th dose of ketoprofen. Of the 61 samples collected, ketoprofen was undetectable (<20 mcg/L) in 17 of the samples. The authors assumed a milk concentration of 20 mcg/L for undetectable samples and calculated an average milk concentration of 57 mcg/L (range 20 to 177 mcg/L). A fully breastfed infant would receive an average dosage of 8.5 mcg/kg daily or 0.31% of the maternal weight-adjusted dosage.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acetaminophen,Flurbiprofen,Ibuprofen,Indomethacin,Naproxen,Piroxicam


References:


1. Jacqz-Aigrain E, Serreau R, Boissinot C et al. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007;29:815-8. PMID:18043481



Substance Identification:




Substance Name:

Ketoprofen

CAS Registry Number:

22071-15-4

Drug Class:


  • Analgesic Agents

  • Nonsteroidal Antiinflammatory Agents


  • Administrative Information:




    LactMed Record Number:


    624


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.